This modified definition of receptor occupancy defined by the del Castillo-Katz model now allows us to re-define R. P. Stephenson’s original postulate in Eq. (1.0) as follows:
![Stimulus (SA) = e^*_A \delta_{occupied(A)} = S = e^*_A \frac {[A]}{K_{effective} + [A]}](http://s0.wp.com/latex.php?latex=Stimulus+%28SA%29+%3D+%C2%A0e%5E%2A_A%C2%A0+%5Cdelta_%7Boccupied%28A%29%7D+%3D+S+%3D+e%5E%2A_A+%C2%A0%5Cfrac+%7B%5BA%5D%7D%7BK_%7Beffective%7D+%2B+%5BA%5D%7D&bg=ffffff&fg=000&s=0 "Stimulus (SA) = e^*_A \delta_{occupied(A)} = S = e^*_A \frac {[A]}{K_{effective} + [A]}")
Black and Leff Operational model of Efficacy
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